New paper shows how the gut microbiome can help maintain the peace with the immune system

We have trillions of bugs in our guts, many of them good for us – or at least not harmful – and we can’t afford to wage war against them all. A new study in the prestigious journal Science shows how, in mice, signals from some microbes in the microbiome lead to specialist immune cells called Tregs (T regulatory cells) damping down the immune response.

It may be that the inflammation seen in ME/CFS patients in Dr Lipkin’s earlier study is being triggered by problems in the microbiome, either as a reaction against ‘bad’ microbes, or because the normal gut regulation of the immune system isn’t working properly.