The Microbe Discovery Project

A patient-led initiative supporting Dr. Ian Lipkin & Dr. Mady Hornig's ME/CFS research
at the Columbia University Center for Infection and Immunity, Mailman School of Public Health, New York.

Ian Lipkin’s CII team shows gut bacteria in ME/CFS may influence disease severity

Ian Lipkin’s CII team shows gut bacteria in ME/CFS may influence disease severity

  Anticipated work from the CII teams’ early investigative research into ME/CFS is starting to be published. The new study in the journal Microbiome from Drs Ian Lipkin and Mady Horning at Columbia University Center for Infection and Immunity (CII) finds abnormal levels of certain types of bacteria in the gut microbiome of ME/CFS patients.Read more about Ian Lipkin’s CII team shows gut bacteria in ME/CFS may influence disease severity[…]

Cort Johnson: ‘Peterson’s Atypical Subset Opens New View of ME/CFS in Columbia/Simmaron Publication’

Cort Johnson: ‘Peterson’s Atypical Subset Opens New View of ME/CFS in Columbia/Simmaron Publication’

Cort Johnson writes a stunning breakdown on the recent research differentiating Atypical and Classical ME/CFS by scientists at Columbia CII and Simmaron Research The recent paper ‘Immune network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome with atypical and classical presentations’ by Dr. Mady Hornig et al is a complex paper. Cort Johnson from Health Rising has done an excellentRead more about Cort Johnson: ‘Peterson’s Atypical Subset Opens New View of ME/CFS in Columbia/Simmaron Publication’[…]

New Research Discovers Evidence of Atypical & Classical ME/CFS

New Research Discovers Evidence of Atypical & Classical ME/CFS

This latest research is the first to report evidence differentiating Atypical and Classical ME/CFS The researchers measured 51 different cytokines (immune messenger molecules) in cerebrospinal fluid. Their immune network analysis of these cytokines provided evidence that Atypical and Classical cases of ME/CFS have differing immune signatures within the central nervous system. This work suggests distinct presentations and course of diseaseRead more about New Research Discovers Evidence of Atypical & Classical ME/CFS[…]

The ME/CFS Biomarker Rollercoaster

The ME/CFS Biomarker Rollercoaster

    Biomarkers are a holy grail for ME/CFS because they have the potential to help diagnose disease, track disease progression or progress and help inform which treatments might help. The need for biomarkers is immense and researchers will identify many possible ones. It is encouraging that there have been more possible biomarker reports recently. It canRead more about The ME/CFS Biomarker Rollercoaster[…]

ME/CFS Hits Nature News & A Call Out For An Urgent Advocacy Action!

ME/CFS Hits Nature News & A Call Out For An Urgent Advocacy Action!

It is wonderful to see an article in Nature covering emerging science in ME/CFS and quoting top scientists who are working on the disease. Not long ago in February, NewScientist featured a great piece and now Nature has published an excellent peice by Amy Maxemen, ‘Biological underpinnings of chronic fatigue syndrome begin to emerge’ with the sub-heading “Gut bacteria and altered metabolic pathways are suspects in mysterious disease.” IsRead more about ME/CFS Hits Nature News & A Call Out For An Urgent Advocacy Action![…]

NIH RFA’s! Money talks – what will this mean for Columbia CII’s ME/CFS research!?

NIH RFA’s! Money talks – what will this mean for Columbia CII’s ME/CFS research!?

The National Institutes of Health finally announced their Request for Applications for a funding opportunity for the first ever Data Management Center and Collaborative Research Centers for ME/CFS.   After decades of effort by people with ME/CFS, their families, advocates and researchers to get research dollars increased for ME/CFS, the much anticipated announcements finally came. With bated breathRead more about NIH RFA’s! Money talks – what will this mean for Columbia CII’s ME/CFS research!?[…]

News round up: Momentum is building for ME/CFS!

News round up: Momentum is building for ME/CFS!

Our Microbe Discovery Project team had some time unplugged through the holiday period but while we were away momentum was building in the ME/CFS research world! Straight off the bat there was some big news from Norway just before Christmas! Drs. Fluge and Mella et all AKA the Norwegian team, published a paper titled ‘Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronicRead more about News round up: Momentum is building for ME/CFS![…]

‘Unrest’ is set to show millions the reality of ME/CFS

‘Unrest’ is set to show millions the reality of ME/CFS

‘Unrest’ – a documentary about ME/CFS is poised to reach millions and raise awareness like never before. ‘Unrest’ (formerly known as ‘Canary in a Coalmine’), the highly anticipated documentary film directed by Jennifer Brea, has received widespread praise and recognition. It premiered to the world at the 2017 Sundance Film Festival and claimed the prestigious Special Jury Award inRead more about ‘Unrest’ is set to show millions the reality of ME/CFS[…]

Alzheimer’s and Pathogens: Changing how we understand the microbiome

Alzheimer’s and Pathogens: Changing how we understand the microbiome

The following is a summary with excerpts from Aeon’s “A bug for Alzheimer’s?” which discusses how microbes may be implicated in a chronic brain disease. It may seem not so relevant to ME/CFS, but CII’s own Dr. Mady Hornig discusses the strategies and challenges associated with linking microbiome differences or infections (even infections outside the brain!) to complex brainRead more about Alzheimer’s and Pathogens: Changing how we understand the microbiome[…]